This is the third woe and the fifth transgression specified in this chapter.
Human wisdom and prudence, are self-assumptions of facts and realities that do not exist.
Wise in ones own eyes means being inflated with false opinions or beliefs, based not on truth, but on ones own knowledge, regardless of where it comes from, and demonstrating a self confidence in those opinions even when they are false.
This can be easily demonstrated with the example of kids and foods. They look at something and decide immediately if they like it or not. It may be the package, or the look of the food, but their decision is based solely on an opinion that lacks any knowledge or evidence, or even tasting the food.
They like or dislike, without proofs of any kind, which could easily be changed with an empirical approach, which is simply tasting the food, with objectivity of course, and then deciding.
As people get older, then even empirical approaches can get twisted. Monkeys have arms and legs, therefore the interpretation is that they are basketball players. Right?
I josh of course, but evolution takes facts and then misinterprets them into wrong conclusions. Likewise, government takes socialism and makes it out to be other than what it really is, a disaster. And the general public will believe the lies.
Anytime, opinions deviate from divine establishment principles, then they are false principles. Anytime spiritual criteria deviates from doctrine, it is false. Anytime analysis deviates from objectivity, it is false.
When people do not possess doctrine in their soul, then they do not have the basis or foundation for being able to orient to self, to life, to God, to reality, and so forth.
Doctrine is the prerequisite for being able to figure out and to understand life and all that is in it.
Without doctrine, you are limited to understanding anything and everything, and that limit will fail you sooner or later. And that failure, is the woe, of this verse.
Wrong conclusions lead to misunderstanding and wrong decisions, and eventually great loss and disaster.
End of study