Both historically and spiritually, this verse as with many of the passages in the Bible, carry contemporary, personal, and prophetic applications.
Contemporary applies to Isaiah’s day. Personally, applies to each and every believer throughout history, which includes you and me. Prophetically applies to the future and final days of human history, during the period commonly known as the Tribulation, or the ‘last days.’
Jerusalem and Judah are actual geographical areas. Jerusalem is the city and Judah is the nation.
However, they also represent the nation of believers, or family of God, for whom doctrine and the spiritual life have been made available.
The nation of Judah symbolized the entire family of believers. The city of Jerusalem means the city of peace and represents spiritually mature believers. Zion, not mentioned here, is the mountain that exists within the city of Jerusalem and represents the dwelling of God, or Bible doctrine.
The writer here gives the reason of the collapse of society, previously mentioned in the prior verses. And that is namely that they have turned away from truth. They have turned away from the study of the scriptures. When the capital collapses, then the nation collapses. When the world lacks mature believers, then even believers in general, fail in their spiritual lives.
Historically the city and the nation turned away from God and thus were overrun by their enemies.
Personally, when you turn away from the legitimate spiritual life, even if you try to substitute something else, your life will become miserable. Doctrine is truth, rejecting truth means pursuing lies. Lies are not reality and always end in disaster.
When the Tribulation begins, then all of society even throughout the entire world, will be in the same boat, spiritually empty and riding the horrendous disasters that will ensue throughout that entire seven year period.
Their trouble is of their own making. All trouble in everyone’s life, is due not to God, but to their (your) own indifference, due to disrespect, due to arrogance, due to a turning away from God.
Gods attention must be obtained in accordance with His rules, not yours.
To provoke the eyes of His glory, is an expression for God initiating discipline and/or judgment. His glory is truth and more, and judgment is the application of His justice against all that is in opposition to truth.